Alternative uses of Cellulose, Starch, and Chitosan-based Hydrogels: Literature Review and Bibliometric Analysis
Abstract
In recent decades, the study of biopolymers and their applications has taken on an important role thanks to their cost-effectiveness, non-toxicity, biocompatibility, and abundance, leading to the development of a large number of polysaccharide-based biomaterials useful in multiple areas. For this reason, the objective of this research was to explore and analyze the alternative uses of cellulose-, starch-, and chitosan-based hydrogels through a review of scientific literature and a bibliometric analysis, in order to identify research trends, emerging applications, and opportunities for the development of new sustainable materials in different areas of knowledge. The literature review was carried out in the Scopus database using search criteria related to the main topic. A bibliometric and co-occurrence analysis was performed based on indicators that helped to recognize patterns in scientific production and visualize the evolution of interest in this field over the years. There was evidence of steady growth in the study of hydrogels, with China being the country with the highest scientific production worldwide and Brazil being the South American country with the most reported studies. Likewise, it was found that research on starch hydrogels focuses mainly on their structural properties and their use in the food industry; in cellulose hydrogels, studies on nanofibers and their incorporation into energy applications stand out; while in chitosan hydrogels, their uses in controlled drug release and environmental treatment processes are highlighted. This study shows that cellulose-, starch-, and chitosan-based hydrogels have enormous potential in areas as diverse as biomedicine, the food industry, environmental engineering, and the development of advanced materials. By combining the literature review with bibliometric analysis, a clear and up-to-date overview of the state of the art is provided, which in turn allows for the recognition of trends, knowledge gaps, and possible avenues for future research. In this way, the work not only summarizes the current landscape but also serves as a reference guide for researchers interested in the design of sustainable materials and their applications.
Authors
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Candelaria Tejada
Colombia
Candelaria Tejada
Ingeniera Química, Magister en Ingeniería Ambiental, Profesora Titular del programa del programa de Ingeniería Química, Facultad de Ingeniería, Universidad de Cartagena, Cartagena, Colombia, Process Design and Biomass Utilization Research Group (IDAB), Avenida del Consulado Calle 30 No. 48 – 152, Colombia; 130015
References
Amiri, F., Kabiri, K., Bouhendi, H., Abdollahi, H., Najafi, V., & Karami, Z. (2019). High gel-strength hybrid hydrogels based on modified starch through surface cross-linking technique. Polymer Bulletin, 76(8), 4047–4068. https://doi.org/10.1007/s00289-018-2593-6
Andrade del Olmo, J., Alonso, J. M., Sáez-Martínez, V., Benito-Cid, S., Moreno-Benítez, I., Bengoa-Larrauri, M., Pérez-González, R., Vilas-Vilela, J. L., & Pérez-Álvarez, L. (2022). Self-healing, antibacterial and anti-inflammatory chitosan-PEG hydrogels for ulcerated skin wound healing and drug delivery. Biomaterials Advances, 139, 212992. https://doi.org/10.1016/j.bioadv.2022.212992
Arayaphan, J., Maijan, P., Boonsuk, P., & Chantarak, S. (2021). Synthesis of photodegradable cassava starch-based double network hydrogel with high mechanical stability for effective removal of methylene blue. International Journal of Biological Macromolecules, 168, 875–886. https://doi.org/10.1016/j.ijbiomac.2020.11.166
Azimov, A., Bolysbek, A., Iztleuov, G., Ashirbayev, Z., Amirbekova, E., & Duissebayev, S. (2025). Development and Characterization of Novel Biodegradable Hydrogels With Controlled Moisture Release for Smart Packaging Materials. Polymer Engineering and Science, 1–11. https://doi.org/10.1002/pen.70053
Bello, K., Sarojini, B. K., & Narayana, B. (2019). Design and fabrication of environmentally benign cellulose based hydrogel matrix for selective adsorption of toxic dyes from industrial effluvia. Journal of Polymer Research, 26(3). https://doi.org/10.1007/s10965-019-1724-6
Boccia, A. C., Pulvirenti, A., Cerruti, P., Silvetti, T., & Brasca, M. (2024). Antimicrobial starch-based cryogels and hydrogels for dual-active food packaging applications. Carbohydrate Polymers, 342, 122340. https://doi.org/10.1016/J.CARBPOL.2024.122340
Bora, A., & Karak, N. (2022). Starch and itaconic acid-based superabsorbent hydrogels for agricultural application. European Polymer Journal, 176(May), 111430. https://doi.org/10.1016/j.eurpolymj.2022.111430
Chamorro, A. F., Palencia, M., & Arrieta, Á. A. (2024). Development of High-Efficiency Fertilizer by Hydrogels Obtained from Cassava Starch and Citric Acid for Slow Release of Ammonium and Potassium. Gels, 10(7), 434. https://doi.org/10.3390/GELS10070434
Chen, M., An, X., Zhao, F., Chen, P., Wang, J., Zhang, M., & Lu, A. (2025). Boosting Sensitivity of Cellulose Pressure Sensor via Hierarchically Porous Structure. Nano-Micro Letters, 17(1), 1–16. https://doi.org/10.1007/S40820-025-01718-Z
Cuenot, S., Gélébart, P., Sinquin, C., Colliec-Jouault, S., & Zykwinska, A. (2022). Mechanical relaxations of hydrogels governed by their physical or chemical crosslinks. Journal of the Mechanical Behavior of Biomedical Materials, 133, 105343. https://doi.org/10.1016/j.jmbbm.2022.105343
Das, S. K., & Ghosh, G. K. (2022). Hydrogel-biochar composite for agricultural applications and controlled release fertilizer: A step towards pollution free environment. Energy, 242, 122977. https://doi.org/10.1016/j.energy.2021.122977
Ding, F., Fu, L., Huang, X., Shi, J., Povey, M., & Zou, X. (2025). Self-healing carboxymethyl chitosan hydrogel with anthocyanin for monitoring the spoilage of flesh foods. Food Hydrocolloids, 165, 111270. https://doi.org/10.1016/J.FOODHYD.2025.111270
Dziadek, M., Dziadek, K., Salagierski, S., Drozdowska, M., Serafim, A., Stancu, I. C., Szatkowski, P., Kopec, A., Rajzer, I., Douglas, T. E. L., & Cholewa-Kowalska, K. (2022). Newly crosslinked chitosan- and chitosan-pectin-based hydrogels with high antioxidant and potential anticancer activity. Carbohydrate Polymers, 290, 119486. https://doi.org/10.1016/j.carbpol.2022.119486
Eghbali, H., Sadeghi, M., noroozi, M., & Movahedifar, F. (2023). Vanillin crosslinked 3D porous chitosan hydrogel for biomedicine applications: Preparation and characterization. Journal of the Mechanical Behavior of Biomedical Materials, 145, 106044. https://doi.org/10.1016/J.JMBBM.2023.106044
Eivazzadeh-Keihan, R., Radinekiyan, F., Maleki, A., Salimi Bani, M., Hajizadeh, Z., & Asgharnasl, S. (2019). A novel biocompatible core-shell magnetic nanocomposite based on cross-linked chitosan hydrogels for in vitro hyperthermia of cancer therapy. International Journal of Biological Macromolecules, 140, 407–414. https://doi.org/10.1016/j.ijbiomac.2019.08.031
El-saied, H. A. aidy, & El-Fawal, E. M. (2021). Green superabsorbent nanocomposite hydrogels for high-efficiency adsorption and photo-degradation/reduction of toxic pollutants from waste water. Polymer Testing, 97, 107134. https://doi.org/10.1016/j.polymertesting.2021.107134
Fan, X., Wang, X., Cai, Y., Xie, H., Han, S., & Hao, C. (2022). Functionalized cotton charcoal/chitosan biomass-based hydrogel for capturing Pb2+, Cu2+ and MB. Journal of Hazardous Materials, 423, 127191. https://doi.org/10.1016/j.jhazmat.2021.127191
Feng, Q., Luo, Y., Liang, M., Cao, Y., Wang, L. S., Liu, C., Zhang, X., Ren, L., Wang, Y., Wang, D., Zhu, Y., Zhang, Y., Xiao, B., & Li, N. (2025). Rhizobacteria protective hydrogel to promote plant growth and adaption to acidic soil. Nature Communications, 16(1), 1684. https://doi.org/10.1038/s41467-025-56988-3
Fu, L. H., Qi, C., Ma, M. G., & Wan, P. (2019). Multifunctional cellulose-based hydrogels for biomedical applications. Journal of Materials Chemistry B, 7(10), 1541–1562. https://doi.org/10.1039/c8tb02331j
Godiya, C. B., Revadekar, C., Kim, J., & Park, B. J. (2022). Amine-bilayer-functionalized cellulose-chitosan composite hydrogel for the efficient uptake of hazardous metal cations and catalysis in polluted water. Journal of Hazardous Materials, 436, 129112. https://doi.org/10.1016/j.jhazmat.2022.129112
Han, D., Zhao, H., Gao, L., Qin, Z., Ma, J., Han, Y., & Jiao, T. (2021). Preparation of carboxymethyl chitosan/phytic acid composite hydrogels for rapid dye adsorption in wastewater treatment. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 628, 127355. https://doi.org/10.1016/j.colsurfa.2021.127355
Hoang, H. T., Vu, T. T., Karthika, V., Jo, S. H., Jo, Y. J., Seo, J. W., Oh, C. W., Park, S. H., & Lim, K. T. (2022). Dual cross-linked chitosan/alginate hydrogels prepared by Nb-Tz ‘click’ reaction for pH responsive drug delivery. Carbohydrate Polymers, 288, 119389. https://doi.org/10.1016/j.carbpol.2022.119389
Huang, L., Han, X., Mo, Q., Wang, Y., Wang, X., Li, Y., Huang, C., & Duan, Q. (2023). Preparation and properties of modified cassava starch slow-release hydrogel with acid and alkali resistance. Industrial Crops and Products, 206, 117699. https://doi.org/10.1016/J.INDCROP.2023.117699
Huang, Y. L., & Wang, D. M. (2023). Characterization of Composite Film of Gelatin and Squid Pen Chitosan Obtained by High Hydrostatic Pressure. Polymers, 15(7), 1608. https://doi.org/10.3390/POLYM15071608
Iqbal, D. N., Tariq, Z., Philips, B., Sadiqa, A., Ahmad, M., Al-Ahmary, K. M., Ali, I., & Ahmed, M. (2024). Nanocellulose/wood ash-reinforced starch–chitosan hydrogel composites for soil conditioning and their impact on pea plant growth. RSC Advances, 14(13), 8652–8664. https://doi.org/10.1039/D3RA08725E
Istiqomah, A., Prasetyo, W. E., Firdaus, M., & Kusumaningsih, T. (2022). Valorisation of lemongrass essential oils onto chitosan-starch film for sustainable active packaging: Greatly enhanced antibacterial and antioxidant activity. International Journal of Biological Macromolecules, 210, 669–681. https://doi.org/10.1016/j.ijbiomac.2022.04.223
Jenisha, S., Subhapriya, P., Lakshmi Priya, A., Murali Krishnan, M., & Dhanapal, V. (2024). Optimization, experimental and theoretical investigation of modified guar-gum and poly(acrylic acid) based smart hydrogel for controlled release applications in the agricultural field. Materials Today Communications, 41, 110748. https://doi.org/10.1016/J.MTCOMM.2024.110748
Jian, J., Xie, Y., Gao, S., Sun, Y., Lai, C., Wang, J., Wang, C., Chu, F., & Zhang, D. (2022). A skin-inspired biomimetic strategy to fabricate cellulose enhanced antibacterial hydrogels as strain sensors. Carbohydrate Polymers, 294, 119760. https://doi.org/10.1016/j.carbpol.2022.119760
Jiang, X., Zeng, F., Yang, X., Jian, C., Zhang, L., Yu, A., & Lu, A. (2022). Injectable self-healing cellulose hydrogel based on host-guest interactions and acylhydrazone bonds for sustained cancer therapy. Acta Biomaterialia, 141, 102–113. https://doi.org/10.1016/j.actbio.2021.12.036
Kadri, H. J., Ahmed, F., Rahman, M. H., & Mondal, M. I. H. (2025). Synthesis and characterisation of starch-g-polyacrylamide-co-polylactic acid hydrogel for the potential wound dressing application. Polymer Bulletin, 82(13), 7917–7941. https://doi.org/10.1007/S00289-025-05840-1
Kadry, G., & El-Gawad, H. A. (2023). Rice straw derived cellulose-based hydrogels synthesis and applications as water reservoir system. International Journal of Biological Macromolecules, 253, 127058. https://doi.org/10.1016/J.IJBIOMAC.2023.127058
Karkhani, R., & Javanbakht, V. (2022). A polyurethane foam membrane filled with double cross-linked chitosan/carboxymethyl cellulose gel and decorated with ZSM-5 nano zeolite: Simultaneous dye removal. International Journal of Biological Macromolecules, 213, 699–717. https://doi.org/10.1016/j.ijbiomac.2022.05.120
Kassem, I., Ablouh, E. H., El Bouchtaoui, F. Z., Kassab, Z., Hannache, H., Sehaqui, H., & El Achaby, M. (2022). Biodegradable all-cellulose composite hydrogel as eco-friendly and efficient coating material for slow-release MAP fertilizer. Progress in Organic Coatings, 162, 106575. https://doi.org/10.1016/j.porgcoat.2021.106575
Khosravi, N., Youseftabar-miri, L., Divsar, F., Hallajian, S., & Hafezi, K. (2022). Development and evaluation of chitosan-g-poly(acrylic acid-co-acrylamide) hydrogel composite containing gabapentin for in vitro controlled release. Journal of Molecular Structure, 1270, 133934. https://doi.org/10.1016/j.molstruc.2022.133934
Kim, R. E., Koo, E. Y., Kim, E. Y., Shin, S. Y., Park, S. A., Huh, K. M., & Kim, M. K. (2025). Injectable glycol chitosan thermogel loaded with placental mesenchymal stem cells secretome for enhanced wound healing and tissue regeneration. Colloids and Surfaces B: Biointerfaces, 254, 114851. https://doi.org/10.1016/J.COLSURFB.2025.114851
Kobryń, J., Witkowska, A., Raszewski, B., Zięba, T., & Musiał, W. (2025). Modified starch as a new co-excipient in hydrophilic gels for prolonged drug delivery. Scientific Reports, 15(1), 19255. https://doi.org/10.1038/S41598-025-88179-X
Kongseng, P., Amornpitoksuk, P., & Chantarak, S. (2022). Development of multifunctional hydrogel composite based on poly(vinyl alcohol-g-acrylamide) for removal and photocatalytic degradation of organic dyes. Reactive and Functional Polymers, 172, 105207. https://doi.org/10.1016/j.reactfunctpolym.2022.105207
Li, B., Zhu, X., Xu, C., Yu, J., Zhang, X., & Fan, Y. (2025). Facile surface modification of cellulose nanofiber with “cross-linkable” internal alkene by syringaldehyde in aqueous medium towards mechanically robust nanocomposite hydrogels. Carbohydrate Polymers, 367, 124026. https://doi.org/10.1016/J.CARBPOL.2025.124026
Li, P., Zhou, M., Liu, H., Lei, H., Jian, B., & Liu, R. (2022). Journal of Environmental Chemical Engineering Preparation of green magnetic hydrogel from soybean residue cellulose for effective and rapid removal of copper ions from wastewater. Journal of Environmental Chemical Engineering, 10(5), 108213. https://doi.org/10.1016/j.jece.2022.108213
Liao, Y., Zhang, L., Xu, X., Yang, W., He, F., Jiang, Z., Chen, N., Zhou, Y., & Li, Y. (2025). Shape-Stable, Phase Change Composite Hydrogel for Solar Thermal Energy Storage and Electrothermal Conversion. ACS Applied Polymer Materials, 7(7), 4584–4595. https://doi.org/10.1021/ACSAPM.5C00340
Lin, Q., Li, H., Ji, N., Dai, L., Xiong, L., & Sun, Q. (2021). Self-healing, stretchable, and freezing-resistant hydroxypropyl starch-based double-network hydrogels. Carbohydrate Polymers, 251, 116982. https://doi.org/10.1016/j.carbpol.2020.116982
Lin, Z., Huang, R., Wu, J., Penkova, A., Qi, W., He, Z., & Su, R. (2022). Injectable self-healing nanocellulose hydrogels crosslinked by aluminum: Cellulose nanocrystals vs. cellulose nanofibrils. Chinese Journal of Chemical Engineering, 50, 389–397. https://doi.org/10.1016/j.cjche.2022.04.026
Lin, Z., Li, F., Liu, X., & Su, J. (2023). Preparation of corn starch/acrylic acid/itaconic acid ion exchange hydrogel and its adsorption properties for copper and lead ions in wastewater. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 671, 131668. https://doi.org/10.1016/J.COLSURFA.2023.131668
Lipatova, I. M., Yusova, A. A., & Makarova, L. I. (2022). Functional films based on mechanoactivated starch with prolonged release of preservative. Food Bioscience, 47, 101694. https://doi.org/10.1016/j.fbio.2022.101694
Liu, Y., Zhang, Y. F., Tang, J., Tan, Y., Lei, H., Li, Y., Huang, P., & Li, Y. (2022). Efficient removal and recycle of acid blue 93 dye from aqueous solution by acrolein crosslinked chitosan hydrogel. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 632, 127825. https://doi.org/10.1016/j.colsurfa.2021.127825
Lv, H., Wang, S., Wang, Z., Meng, W., Han, X., & Pu, J. (2022). Fluorescent cellulose-based hydrogel with carboxymethyl cellulose and carbon quantum dots for information storage and fluorescent anti-counterfeiting. Cellulose, 29(11), 6193–6204. https://doi.org/10.1007/s10570-022-04643-1
Ma, J., Zhu, J., Zhou, S., Zhao, C., Liu, C., Xin, Z., Cai, J., He, J., Feng, P., Guo, L., & Tao, X. (2025). Multifunctional starch-based conductive hydrogels for smart sensors and flexible supercapacitors. International Journal of Biological Macromolecules, 302, 140430. https://doi.org/10.1016/J.IJBIOMAC.2025.140430
Mahmoud, M., Mohamed, A. K., & Salam, M. A. (2021). Self-decoration of N-doped graphene oxide 3-D hydrogel onto magnetic shrimp shell biochar for enhanced removal of hexavalent chromium. Journal of Hazardous Materials, 408, 124951. https://doi.org/10.1016/j.jhazmat.2020.124951
Majeed, N., Shah, N., Hameed, A., Shah, M., Gul, H., Ullah, N., Rehan, T., Elodemi, M., Ogaly, H. A., Khan, A., & Al-Harrasi, A. (2025). Synthesis and characterization of multifunctional chitosan-grafted hydrogel for controlled drug delivery and electrochemical applications. Journal of Drug Delivery Science and Technology, 107, 106770. https://doi.org/10.1016/J.JDDST.2025.106770
Maroufi, L. Y., Tabibiazar, M., Ghorbani, M., & Jahanban-Esfahlan, A. (2021). Fabrication and characterization of novel antibacterial chitosan/dialdehyde guar gum hydrogels containing pomegranate peel extract for active food packaging application. International Journal of Biological Macromolecules, 187, 179–188. https://doi.org/10.1016/j.ijbiomac.2021.07.126
Nguyen, H. T., Phuong, V. N., Van, T. N., Thi, P. N., Dinh Thi Lan, P., Pham, H. T., & Cao, H. T. (2020). Low-cost hydrogel derived from agro-waste for veterinary antibiotic removal: Optimization, kinetics, and toxicity evaluation. Environmental Technology and Innovation, 20, 101098. https://doi.org/10.1016/j.eti.2020.101098
Ngwabebhoh, F. A., Zandraa, O., Patwa, R., Saha, N., Capáková, Z., & Saha, P. (2021). Self-crosslinked chitosan/dialdehyde xanthan gum blended hypromellose hydrogel for the controlled delivery of ampicillin, minocycline and rifampicin. International Journal of Biological Macromolecules, 167, 1468–1478. https://doi.org/10.1016/j.ijbiomac.2020.11.100
Pan, W., Dai, C., Li, Y., Yin, Y., Gong, L., Machuki, J. O. achwa, Yang, Y., Qiu, S., Guo, K., & Gao, F. (2020). PRP-chitosan thermoresponsive hydrogel combined with black phosphorus nanosheets as injectable biomaterial for biotherapy and phototherapy treatment of rheumatoid arthritis. Biomaterials, 239, 119851. https://doi.org/10.1016/j.biomaterials.2020.119851
Pan, X., Li, Y., Pang, W., Xue, Y., Wang, Z., Jiang, C., Shen, C., Liu, Q., & Liu, L. (2022). Preparation, characterisation and comparison of glabridin-loaded hydrogel-forming microneedles by chemical and physical cross-linking. International Journal of Pharmaceutics, 617, 121612. https://doi.org/10.1016/j.ijpharm.2022.121612
Patil, G., Pawar, R., Jadhav, S., & Ghormade, V. (2022). A chitosan based multimodal “soft” hydrogel for rapid hemostasis of non-compressible hemorrhages and its mode of action. Carbohydrate Polymer Technologies and Applications, 4, 100237. https://doi.org/10.1016/j.carpta.2022.100237
Pérez-Calderón, J., Santos, M. V., & Zaritzky, N. (2020). Synthesis, characterization and application of cross-linked chitosan/oxalic acid hydrogels to improve azo dye (Reactive Red 195) adsorption. Reactive and Functional Polymers, 155, 104699. https://doi.org/10.1016/j.reactfunctpolym.2020.104699
Phatchayawat, P. P., Khamkeaw, A., Yodmuang, S., & Phisalaphong, M. (2022). 3D bacterial cellulose-chitosan-alginate-gelatin hydrogel scaffold for cartilage tissue engineering. Biochemical Engineering Journal, 184, 108476. https://doi.org/10.1016/j.bej.2022.108476
Qian, F., Han, Y., Han, Z., Zhang, D., Zhang, L., Zhao, G., Li, S., Jin, G., Yu, R., & Liu, H. (2021). In Situ implantable, post-trauma microenvironment-responsive, ROS Depletion Hydrogels for the treatment of Traumatic brain injury. Biomaterials, 270, 120675. https://doi.org/10.1016/j.biomaterials.2021.120675
Radoor, S., Karayil, J., Jayakumar, A., Kandel, D. R., Kim, J. T., Siengchin, S., & Lee, J. (2024). Recent advances in cellulose- and alginate-based hydrogels for water and wastewater treatment: A review. Carbohydrate Polymers, 323, 121339. https://doi.org/10.1016/j.carbpol.2023.121339
Radoor, S., Kassahun, S. K., & Kim, H. (2024). Selective adsorption of cationic dye by κ-carrageenan-potato starch bio-hydrogel: Kinetics, isotherm, and thermodynamic studies. International Journal of Biological Macromolecules, 281, 136377. https://doi.org/10.1016/J.IJBIOMAC.2024.136377
Ragab, A., El-Badry, N., Tamer, N., Naas, A., Hamdy, A., Tawakey, S. H., Hassan, A. H. A., & Salim, A. I. (2025). Biodegradable chitosan/PVA-based hydrogel incorporating green synthesized silver nanoparticles for wound healing applications. BMC Chemistry, 19(1), 1–16. https://doi.org/10.1186/S13065-025-01564-5
Ren, J., Wang, X., Zhao, L., Li, M., & Yang, W. (2022). Double Network Gelatin/Chitosan Hydrogel Effective Removal of Dyes from Aqueous Solutions. Journal of Polymers and the Environment, 30(5), 2007–2021. https://doi.org/10.1007/s10924-021-02327-8
Ren, T., Peng, J., Yuan, H., Liu, Z., Li, Q., Ma, Q., Li, X., Guo, X., & Wu, Y. (2022). Nanocellulose-based hydrogel incorporating silver nanoclusters for sensitive detection and efficient removal of hexavalent chromium. European Polymer Journal, 175, 111343. https://doi.org/10.1016/j.eurpolymj.2022.111343
Roquero, D. M., & Katz, E. (2022). “Smart” alginate hydrogels in biosensing, bioactuation and biocomputing: State-of-the-art and perspectives. Sensors and Actuators Reports, 4, 100095. https://doi.org/10.1016/j.snr.2022.100095
Salehi, B., Zhang, B., Nowlin, K., Wang, L., & Shahbazi, A. (2024). A multifunctional cellulose- and starch-based composite hydrogel with iron-modified biochar particles for enhancing microalgae growth. Carbohydrate Polymers, 327, 121657. https://doi.org/10.1016/J.CARBPOL.2023.121657
Saraiva, N., Cavaco, G., Portela, R. P., Leal, C. R., Almeida, A. P. C., Sobral, R. G., & Almeida, P. L. (2022). Crosslinked bacterial cellulose hydrogels for biomedical applications. European Polymer Journal, 177, 111438. https://doi.org/10.1016/j.eurpolymj.2022.111438
Sarmah, D., Rather, M. A., Sarkar, A., Mandal, M., Sankaranarayanan, K., & Karak, N. (2023). Self-cross-linked starch/chitosan hydrogel as a biocompatible vehicle for controlled release of drug. International Journal of Biological Macromolecules, 237, 124206. https://doi.org/10.1016/J.IJBIOMAC.2023.124206
Sharma, P., Sharma, M., Yadav, L., Agarwal, M., & Gupta, R. (2025). Sustainable solution for wastewater management: Fabrication of cost-effective β-cyclodextrin incorporated chitosan polyvinyl alcohol composite hydrogel film for the efficient adsorption of anionic congo red and tartrazine dyes. Separation and Purification Technology, 355, 129750. https://doi.org/10.1016/J.SEPPUR.2024.129750
Sima, H., Liu, B., Shi, X., & Zhang, C. (2025). CNT@CNF/MXene hydrogel with complete conductive network for flexible anti-freeze sensor and electromagnetic shielding. Carbohydrate Polymers, 366, 123825. https://doi.org/10.1016/J.CARBPOL.2025.123825
Snyder, H. (2019). Literature review as a research methodology: An overview and guidelines. Journal of Business Research, 104, 333–339. https://doi.org/10.1016/J.JBUSRES.2019.07.039
Song, Z., Ma, T., Zhi, X., & Du, B. (2021). Cellulosic films reinforced by chitosan-citric complex for meat preservation: Influence of nonenzymatic browning. Carbohydrate Polymers, 272, 118476. https://doi.org/10.1016/j.carbpol.2021.118476
Su, K., Guo, S., Yang, H., Zheng, W., Chen, X., Xu, G., Ang, S., Zhang, K., & Wu, P. (2022). Novel Metallo-hydrogels as a two-in-one agent with potent dyes removal and antimicrobial capacity. Colloid and Interface Science Communications, 49, 100644. https://doi.org/10.1016/j.colcom.2022.100644
Sun, Z., Yin, Y., An, Y., Deng, C., Wei, Z., Jiang, Z., & Duan, X. (2022). Journal of Environmental Chemical Engineering A novel modified carboxymethyl cellulose hydrogel adsorbent for efficient removal of poisonous metals from wastewater : Performance and mechanism. Journal of Environmental Chemical Engineering, 10(4), 108179. https://doi.org/10.1016/j.jece.2022.108179
Tanan, W., Panichpakdee, J., & Saengsuwan, S. (2019). Novel biodegradable hydrogel based on natural polymers: Synthesis, characterization, swelling/reswelling and biodegradability. European Polymer Journal, 112, 678–687. https://doi.org/10.1016/j.eurpolymj.2018.10.033
Tanan, W., Panichpakdee, J., Suwanakood, P., & Saengsuwan, S. (2021). Biodegradable hydrogels of cassava starch-g-polyacrylic acid/natural rubber/polyvinyl alcohol as environmentally friendly and highly efficient coating material for slow-release urea fertilizers. Journal of Industrial and Engineering Chemistry, 101, 237–252. https://doi.org/10.1016/j.jiec.2021.06.008
Tassanapukdee, Y., Prayongpan, P., & Songsrirote, K. (2021). Removal of heavy metal ions from an aqueous solution by CS/PVA/PVP composite hydrogel synthesized using microwaved-assisted irradiation. Environmental Technology and Innovation, 24, 101898. https://doi.org/10.1016/j.eti.2021.101898
Tekko, I. A., Chen, G., Domínguez-Robles, J., Thakur, R. R. S., Hamdan, I. M. N., Vora, L., Larrañeta, E., McElnay, J. C., McCarthy, H. O., Rooney, M., & Donnelly, R. F. (2020). Development and characterisation of novel poly (vinyl alcohol)/poly (vinyl pyrrolidone)-based hydrogel-forming microneedle arrays for enhanced and sustained transdermal delivery of methotrexate. International Journal of Pharmaceutics, 586, 119580. https://doi.org/10.1016/j.ijpharm.2020.119580
Threepopnatkul, P., Sokjorhor, J., Homchan, P., & Khammee, W. (2022). Preparation of hydrogel with self-healing properties based on poly(vinyl alcohol)/corn starch/zeolite/cellulose nanocrystals for wound dressing applications. Materials Today: Proceedings, 52, 2467–2473. https://doi.org/10.1016/J.MATPR.2021.10.432
Trung, T. S., Minh, N. C., Cuong, H. N., Phuong, P. T. D., Dat, P. A., Nam, P. V., & Hoa, N. Van. (2022). Valorization of fish and shrimp wastes to nano-hydroxyapatite/chitosan biocomposite for wastewater treatment. Journal of Science: Advanced Materials and Devices, 7(4), 100485. https://doi.org/10.1016/j.jsamd.2022.100485
Valipour, F., Rahimabadi, E. Z., & Rostamzad, H. (2023). Preparation and characterization of wound healing hydrogel based on fish skin collagen and chitosan cross-linked by dialdehyde starch. International Journal of Biological Macromolecules, 253, 126704. https://doi.org/10.1016/J.IJBIOMAC.2023.126704
Veiga, A., Ribeiro, V., Ramírez-Jiménez, R. A., Aguilar, M. R., Rojo, L., & Oliveira, A. L. (2025). Biofunctional silk sericin hydrogels: A versatile platform with potential for tissue healing and regeneration. Colloids and Surfaces B: Biointerfaces, 255, 114916. https://doi.org/10.1016/J.COLSURFB.2025.114916
Verma, A., Aljohani, K., Aljohani, B. S., Lal, B., Jadeja, Y., Ballal, S., Chahar, M., & Suman, R. (2025). Innovations in cellulose-based hydrogels for enhanced wastewater treatment through adsorption. International Journal of Biological Macromolecules, 303, 140660. https://doi.org/10.1016/J.IJBIOMAC.2025.140660
Vieira, T., Artifon, S. E. S., Cesco, C. T., Vilela, P. B., Becegato, V. A., & Paulino, A. T. (2021). Chitosan-based hydrogels for the sorption of metals and dyes in water: isothermal, kinetic, and thermodynamic evaluations. Colloid and Polymer Science, 299(4), 649–662. https://doi.org/10.1007/s00396-020-04786-2
Waheed, Z., Ahmad, F., Mushtaq, B., Ahmad, S., Habib, S. R., Rasheed, A., Zafar, M. S., Sefat, F., Saeinasab, M., & Azam, F. (2024). Biowaste rice husk derived cellulosic hydrogel incorporating industrial cotton waste nonwoven for wound dressing. International Journal of Biological Macromolecules, 281, 136412. https://doi.org/10.1016/J.IJBIOMAC.2024.136412
Wang, C., Wang, L., Zhang, Q., Cheng, L., Yue, H., Xia, X., & Zhou, H. (2021). Preparation and characterization of apoacynum venetum cellulose nanofibers reinforced chitosan-based composite hydrogels. Colloids and Surfaces B: Biointerfaces, 199, 111441. https://doi.org/10.1016/j.colsurfb.2020.111441
Wang, H., Fang, S., Zuo, M., Li, Z., Yu, X., Tang, X., Sun, Y., Yang, S., Zeng, X., & Lin, L. (2022). Removal of copper ions by cellulose nanocrystal-based hydrogel and reduced adsorbents for its catalytic properties. Cellulose, 29(8), 4525–4537. https://doi.org/10.1007/s10570-022-04547-0
Wang, X., Wei, S., Huang, H., Tang, J., Yu, J., Qin, Z., Gao, W., Deng, S., & Mo, L. (2025). Hofmeister effect and dual-dynamic-bond cross-linking interaction enhanced ionic conductive and balanced mechanical properties hydrogels for flexible sensors. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 725, 137703. https://doi.org/10.1016/J.COLSURFA.2025.137703
Wu, S., Zhang, H., Zhang, Y., Zhao, Y., Xiang, M., Hao, L., & Chen, J. (2025). A novel PNIPAM-Modified polyurethane/carboxymethyl cellulose photo-thermoresponsive hydrogel loaded with gemcitabine to suppress esophageal cancer cells via VEGF-mediated angiogenic pathway inhibition. Journal of Biological Engineering, 19(1), 1–22. https://doi.org/10.1186/S13036-025-00530-Y
Xiao, Q., Cui, Y., Meng, Y., Guo, F., Ruan, X., He, G., & Jiang, X. (2022). PNIPAm hydrogel composite membrane for high-throughput adsorption of biological macromolecules. Separation and Purification Technology, 294, 121224. https://doi.org/10.1016/j.seppur.2022.121224
Xie, Y., Pan, Y., & Cai, P. (2022). Cellulose-based antimicrobial films incroporated with ZnO nanopillars on surface as biodegradable and antimicrobial packaging. Food Chemistry, 368, 130784. https://doi.org/10.1016/j.foodchem.2021.130784
Yang, H., Liu, Y., Kong, L., Kang, L., & Ran, F. (2019). Biopolymer-based carboxylated chitosan hydrogel film crosslinked by HCl as gel polymer electrolyte for all-solid-sate supercapacitors. Journal of Power Sources, 426, 47–54. https://doi.org/10.1016/j.jpowsour.2019.04.023
Yang, J., Duan, A., Shen, L., Liu, Q., Wang, F., & Liu, Y. (2024). Preparation and application of curcumin loaded with citric acid crosslinked chitosan-gelatin hydrogels. International Journal of Biological Macromolecules, 264, 130801. https://doi.org/10.1016/J.IJBIOMAC.2024.130801
Yang, J., Zhang, X., Wang, G., Xu, D., Jia, X., & Song, H. (2025). Multifunctional all-biomass superelastic aerogel evaporator for efficient desalination and wastewater treatment. Separation and Purification Technology, 367, 132893. https://doi.org/10.1016/J.SEPPUR.2025.132893
Yang, Z., Chen, X., Xu, Z., Ji, N., Xiong, L., & Sun, Q. (2021). Anti-freezing starch hydrogels with superior mechanical properties and water retention ability for 3D printing. International Journal of Biological Macromolecules, 190, 382–389. https://doi.org/10.1016/j.ijbiomac.2021.08.235
Zandraa, O., Ngwabebhoh, F. A., Patwa, R., Nguyen, H. T., Motiei, M., Saha, N., Saha, T., & Saha, P. (2021). Development of dual crosslinked mumio-based hydrogel dressing for wound healing application: Physico-chemistry and antimicrobial activity. International Journal of Pharmaceutics, 607, 120952. https://doi.org/10.1016/j.ijpharm.2021.120952
Zeng, S., Zhang, J., Zu, G., & Huang, J. (2021). Transparent, flexible, and multifunctional starch-based double-network hydrogels as high-performance wearable electronics. Carbohydrate Polymers, 267, 118198. https://doi.org/10.1016/j.carbpol.2021.118198
Zhang, H., Zhang, D., Cai, H., Ma, Y., Li, K., Zhang, P., & Guo, Y. (2025). A bacterial cellulose-based multifunctional conductive hydrogel for flexible strain sensors and supercapacitors. Carbohydrate Polymers, 360, 123601. https://doi.org/10.1016/J.CARBPOL.2025.123601
Zhang, L., Bai, X., Liang, Y., Zhang, G., Zou, J., Lai, W., & Fei, P. (2024). Preparation of chitosan derivatives/oxidized carboxymethyl cellulose hydrogels by freeze-thaw method: Synthesis, characterization, and utilization in dye absorption. International Journal of Biological Macromolecules, 282, 136924. https://doi.org/10.1016/J.IJBIOMAC.2024.136924
Zhang, L., Qiao, M., Zheng, H., Vancov, T., Antoniadis, V., Shaheen, S. M., Joseph, S., Chen, C., Shan, S., Chen, H., & Wang, H. (2025). Integrating spectroscopic analysis and theoretical calculations to elucidate the adsorption efficiency and mechanisms of Cd, Pb, and Cu using novel carboxymethyl cellulose/pectin-based hydrogel beads. International Journal of Biological Macromolecules, 305, 141028. https://doi.org/10.1016/J.IJBIOMAC.2025.141028
Zhang, Q., Zhao, L., & Ran, F. (2022). Reducible, recyclable and reusable (3R) hydrogel electrolyte membrane based on Physical&Chemical Bi-networks and reversible sol-gel transition. Renewable Energy, 194, 80–88. https://doi.org/10.1016/j.renene.2022.05.072
Zhao, C., Liu, G., Tan, Q., Gao, M., Chen, G., Huang, X., Xu, X., Li, L., Wang, J., Zhang, Y., & Xu, D. (2023). Polysaccharide-based biopolymer hydrogels for heavy metal detection and adsorption. Journal of Advanced Research, 44, 53–70. https://doi.org/10.1016/J.JARE.2022.04.005
Zhao, W., Huang, B., Zhu, L., Feng, X., Xu, J., Zhang, H., & Yan, S. (2022). International Journal of Biological Macromolecules Printable hydrogels based on starch and natural rubber latex with high toughness and self-healing capability. International Journal of Biological Macromolecules, 218, 580–587. https://doi.org/10.1016/j.ijbiomac.2022.07.148
Zheng, L., Tian, Z., Ai, B., Yang, Y., Zheng, X., Liu, Y., Xiao, D., Sheng, Z., & Qin, J. (2025). Double network hydrogel coating improved avocado freshness preservation: Preparation, testing and mechanism. Food Hydrocolloids, 163, 111085. https://doi.org/10.1016/J.FOODHYD.2025.111085